Nitric oxide reductase, an enzyme, catalyzes the reduction of nitric oxide (NO) to nitrous oxide (N2O).[1][2][3][4] The enzyme participates in nitrogen metabolism and in the microbial defense against nitric oxide toxicity. The catalyzed reaction may be dependent on different participating small molecules: Cytochrome c (EC: 1.7.2.5, Nitric oxide reductase (cytochrome c)), NADPH (EC:1.7.1.14), or Menaquinone (EC:1.7.5.2).
. . . Nitric-oxide reductase . . .
Nitric oxide reductase was assigned Enzyme Commission number (EC) 1.7.2.5. Enzyme Commission numbers are the standard naming system used for enzymes.[5] The EC identifies the class, subclass, sub-subclass, and serial number of the enzyme.[5] Nitric oxide reductase is in Class 1, therefore it is an oxidoreductases.[5]
Nitric oxide reductase belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with other acceptors. The systematic name of this enzyme class is nitrous-oxide:acceptor oxidoreductase (NO-forming). Other names in common use include nitrogen oxide reductase, and nitrous-oxide:(acceptor) oxidoreductase (NO-forming).
Organisms reduce nitrate (NO3−) to nitrogen gas (N2) through the process of denitrification, see Figure 1.[1][2] Two important intermediates of the reduction pathway are nitric oxide (NO) and nitrous oxide (N2O).[1][2] The reducing reaction that transforms NO into N2O is catalyzed by nitric oxide reductase (NOR).[1][2][3][4]
NO is reduced to N2O also to prevent cellular toxicity.[4][6] N2O, a potent greenhouse gas, is released.[1][4]
. . . Nitric-oxide reductase . . .