Tsurumi Station is an interchange between the Keihin-Tōhoku Line and the Tsurumi Line (of which it is a terminus), and is 52.0 km from the northern terminus of the Keihin-Tōhoku Line at Ōmiya Station.
From the north side of the Keihin-Tōhoku Line platform are located, in order, The Tokaido Line passenger train lines in both directions, The Tokaido Line Tokyo-bound freight train tracks, three tracks for trains to stop at overnight, and the Tokaido Line freight train tracks for the direction from Tokyo. None of these have platforms.
Between the Keihin-Tōhoku Line and Tsurumi Line there is a ticket gate, which is a remnant of when the Tsurumi Line was operated by the separate Tsurumi Rinkō Tetsudō Kabushiki Gaisha (鶴見臨港鉄道株式会社).
There is a Midori no Madoguchi staffed ticket office as well as automatic ticket gates. The Keihin-Tōhoku Line platforms are connected to the concourse by escalators and elevators.